Trajectories of quality of life, anxiety and depressive symptomatology, and health-related work productivity after first seizure events

Abstract

Objective: First seizure events are common and may exert an immediate and profound impact on people's lives. Less understood are their long-term consequences. This prospective, longitudinal study aimed to measure and compare psychosocial and health-related work productivity trajectories following first seizure events of various etiologies. Methods: Adults with first seizure events were recruited from five epilepsy centers in Australia and the US between 2020 and 2023. Participants completed questionnaires covering health-related quality of life (HRQOL; EQ-5D-5L, QOLIE-31), anxiety and depressive symptomatology (HADS), and productivity (WPAI) within 6 weeks of their first seizure event, and 6..